Understanding the keys of mother-embryo molecular dialogue in early pregnancy

One of the most important purposes of MELISA Institute is increasing our knowledge about the molecular cross-talk between mother and embryo in the first weeks of pregnancy after conception.

Understanding the keys of the mother-embryo molecular dialogue in early pregnancy allows us to know the interactions occurring in this binomial. We try to approach the problem of recurrent abortion and discover possible markers of pregnancy outcome.


Currently, MELISA is working in the identification of signals characteristic of the mother-embryo interaction during the natural process of conception, analyzing the proteome and transcriptome present in different maternal fluids or tissues such as cervicovaginal mucus, saliva, plasma, serum, blood cells, and cervical smears.

We’re conducting an investigation in which we follow couples seeking pregnancy. We collect samples of cervical mucus, urine, plasma and saliva from the entire conception menstrual cycle. In addition, we have the pregnancy outcome and cervical brush, placenta and cord blood samples.





Our clinical team collects tissue samples that are securely receipt, processed, and stored in our state of the art Biorepository, allowing our team of researchers to work with samples that will help us advance new breakthrough discoveries that will impact the wellbeing of patients.

Sample integrity is essential for laboratory research best practices. Our cold storage unit is equipped with -80 °C freezer banks and liquid nitrogen storage tanks, currently providing our Biorepository with the capacity of preserving 1,400 liters of samples.

 In our biobank, we currently have samples of cervical mucus, urine, plasma and saliva from the whole conceptional menstrual cycle. We also have the ending of each pregnancy studied with samples of cervical brush, placenta and cord blood.