Medical Hypotheses – Popperian epidemiology and the logic of bi-conditional modus tollens arguments for refutational analysis of randomised controlled trials

“According to this popperian model, applicability of the randomised controlled trial (RCT) results to clinical practice implies transferring of all its empirical content, in other words, the totality of its truth and falsity contents. Thus, to ignore the explicit falsity-content of a RCT such as RALES may jeopardise its potential benefits in clinical practice as suggested by recent studies.”

Koch, E., Otarola, A., Romero, T., Kirschbaum, A., & Ortuzar, E. (2006).

Medical Hypotheses, 67(4), 980-988.

doi:10.1016/j.mehy.2006.03.033

Abstract available here

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